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Semaglutide is a member of a class of drugs that have been used for diabetes management for over a decade - GLP1-RAs (glucagon-like peptide 1 receptor agonists). The weight loss effects of these agents have been known for some time, however, Semaglutide appears to be the "best-in-class" GLP-1 RA for weight loss and was recently approved for weight loss by the FDA under the brand name Wegovy®.
Semaglutide mimics the effect of "feeling full" resulting in a decreased caloric intake. Semaglutide will delay gastric emptying by reducing glucagon secretion in a glucose-dependent manner. The delay in gastric emptying can reduce appetite, improve control of eating, and reduce food cravings.
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